Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jul 2019
[Interleukin-18 combined with kidney injury molecule-1 predict 28-day mortality in patients with acute kidney injury treated with continuous renal replacement therapy in intensive care unit].
To investigate the predict value of interleukin-18 (IL-18) combine with kidney injury molecule-1 (KIM-1) on 28-day mortality in patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT) in intensive care unit (ICU), and to look for the start time of CRRT. ⋯ Urine IL-18 combined with urine KIM-1 has a high predictive value for the prognosis of patients with AKI. For critically ill patients with AKI, initiation of CRRT treatment in AKI 2 stage can significantly reduce the 28-day mortality as compared with that in AKI 3 stage.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jul 2019
[Effects of hydrogen on lung injury in wild-type and Nrf2 gene knockout mice: relationship with Nrf2/HO-1/HMGB1 pathway].
To investigate the key role of nuclear factor E2-related factor 2 (Nrf2) in the treatment of lung injury in sepsis mice by regulating Nrf2/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway. ⋯ H2 inhibits lung injury in septic mice through Nrf2/HO-1/HMGB1 pathway. Nrf2 plays a major role in the treatment of septic lung injury by H2.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jun 2019
Observational Study[Effect of goal-directed therapy bundle based on PiCCO parameters to the prevention and treatment of acute kidney injury in patients after cardiopulmonary bypass cardiac operation: a prospective observational study].
To explore the effect of goal-directed therapy bundle based on pulse-indicated continuous cardiac output (PiCCO) parameters to the prevention and treatment of acute kidney injury (AKI) in patients after cardiopulmonary bypass cardiac operation. ⋯ Goal-directed therapy bundle based on PiCCO parameters reduced the incidence of AKI in patients after cardiopulmonary bypass cardiac operation and improved the severity of systemic disease. However, it did not reduce the duration of mechanical ventilation, length of ICU stay, the incidence of complications (except AKI), short-term mortality. The MAP and CI at 8 hours after ICU admission were independent risk factors that influence the incidence of AKI in patients after cardiopulmonary bypass cardiac operation.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jun 2019
[Prognostic value of microRNA-122 combined with APACHE II score in patient with acute respiratory distress syndrome].
To investigate the prognostic value of microRNA-122 (miR-122) combined with acute physiology and chronic health evaluation II (APACHE II) score in patient with acute respiratory distress syndrome (ARDS), and to provide evidence for the diagnosis and treatment of ARDS. ⋯ Elevated serum miR-122 expression level is associated with disease severity and prognosis of ARDS patients; miR-122 combination with APACHE II score has a high evaluation value on prognosis of ARDS patients.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jun 2019
Randomized Controlled Trial[Application of Narcotrend index and Richmond agitation-sedation score in sedation assessment of patients with short-term mechanical ventilation after pancreatoduodenectomy: a randomized controlled trial].
To explore the feasibility of Narcotrend index (NTI) for digital monitoring of light sedation depth in patients undergoing short-term mechanical ventilation after pancreaticoduodenectomy. ⋯ The application of NTI monitoring to guide light sedation therapy for patients with short-term mechanical ventilation after pancreaticoduodenectomy can better achieve the goal of light sedation.