Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2017
[PK/PD of vancomycin in patients with severe acute pancreatitis combined with augmented renal clearance].
To evaluate the serum trough concentration and the pharmacokinetics/pharmacodynamics (PK/PD) of vancomycin in patients with severe acute pancreatitis (SAP), and analyze the effect of vancomycin continuous infusion for optimizing the characteristics of its PK/PD. ⋯ The serum trough concentration of vancomycin was significantly reduced in SAP patients with ARC. The more serious of the SIRS is, the lower the vancomycin trough concentration is. Vancomycin 24-hour continuous infusion could optimize the PK/PD parameters, decrease the daily dose, increase the clinical effect, and reduce the bacterial resistance.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Aug 2017
Review[Severe disease of immune imbalance in ICU: persistent inflammation immunosuppression catabolism syndrome].
Terminology of persistent inflammation immunosuppression and catabolism syndrome (PICS) is developed based on the concept of multiple organ failure (MOF), which reflect that the preponderance is gradually reversed from pro-inflammation to anti-inflammation, and eventually the state of simultaneously persistent inflammation and severe immunosuppression appeared. Although the improvement of rescue technology and management increase the early survival rates of patient with critical illnesses, the long-term outcomes of most patients are not optimistic. The patients with PICS are difficult to treat or prevent, and are likely to indolent death and have a rising incidence, which is an important challenge to the intensive care unit (ICU). The paper review the understanding of PICS, summarize the specific changes of immune system in PICS, and explore the immunological markers for early recognition of PICS and judgment of immune state in order to provide new thinking for prevention and control of PICS.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Aug 2017
[Evaluation of volume overload in critical patients by monitoring change of cardiac output under bed head raising combined with passive leg raising].
To investigate whether the change of cardiac output (CO) with bed head raising (BHR) combined with passive leg raising (PLR) can be used to assess volume overload in critical patients. ⋯ The change of CO with BHR combined with PLR can be used to accurately evaluate volume overload in patient with critically illness.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Aug 2017
[Predictive value of SOFA, qSOFA score and traditional evaluation index on sepsis prognosis].
Assess the value of several biomarkers and disease severity scores for the prognostic assessment of sepsis. ⋯ SOFA score and qSOFA score cannot take the place of traditional evaluation index for the evaluation of the prognosis of patients with sepsis.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Aug 2017
[Evaluation value of the levels of peripheral blood CD20+ CD24hi CD38hi regulatory B cells on the prognosis of elderly patients with sepsis].
To explore the predicting value of peripheral blood CD20+ CD24hi CD38hi regulatory B cells (Bregs) on the prognosis of elderly patients with sepsis. ⋯ The level of peripheral blood CD20+ CD24hi CD38hi Bregs could predict the clinical outcome of elderly patients with sepsis.