Indian journal of physiology and pharmacology
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Tissue injury and/or infection produce significant alterations in intracellular calcium ion regulation. These alterations in cellular calcium has recently been studied following both short term and long term septic model which uses two types of gram-negative bacteria frequently encountered human abdominal sepsis. ⋯ Calcium-channel blockers attenuate the increased effects of calcium flux. Further anti-cytokines may be useful to prevent septic injury in tissues.