Indian journal of physiology and pharmacology
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Indian J. Physiol. Pharmacol. · Apr 1997
Interaction of ciprofloxacin with diclofenac and paracetamol in relation to it's epileptogenic effect.
A number of fluoroquinolones have shown convulsive potential. The effect of Ciprofloxacin was studied in electroconvulsive seizures in mice using the tonic extensor phase as end point and seizure threshold as observational parameter. ⋯ This was potentiated by diclofenac but paracetamol had no such effect. Though the exact mechanisms involved in this effect are conjectural, role of GABA inhibitory mechanisms is a possibility.