Controlled clinical trials
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Control Clin Trials · Jun 2002
Principles, organization, and operation of a DNA bank for clinical trials: a Department of Veterans Affairs cooperative study.
The mapping and sequencing of the human genome promises rapid growth in understanding the genetically influenced mechanisms that underlie human disease. To realize this promise fully, it is necessary to relate genetic information to clinical phenotypes. ⋯ Concerns about subjects' rights, informed consent, privacy, and ownership of genetic material require attention in the development of DNA banks. In this paper we describe one approach to the solution of these problems that was adopted by one clinical trials group, the Department of Veterans Affairs Cooperative Studies Program.