Controlled clinical trials
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Control Clin Trials · Oct 2004
The utility of partial cross-over designs in early phase randomized prevention trials.
In this note, we outline the benefits of a partial cross-over design for a class of experiments where the interest is the cumulative effect of dose versus placebo. The goal of our design strategy is to answer several complex question efficiently in a phase II setting with a minimal number of assumptions with an eye towards planning a phase III study.