Australian and New Zealand journal of medicine
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The bioavailability and gastrointestinal site of release of enteric coated aspirin tablets ("Rhusal", G. P. Laboratories) were investigated following dosage with single tablets. ⋯ All these tests were consistent with the designed function of the enteric coating. The time course of concentrations of salicylate in saliva rather than in plasma was confirmed as a useful technique for the evaluation of different formulations of aspirin. The acceleration of gastric emptying by metoclopramide is a useful technique for the evaluation of enteric coated tablets.