Folia medica Cracoviensia
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Folia medica Cracoviensia · Jan 1997
Clinical Trial Controlled Clinical Trial[Use of flow cytometry in evaluation of cellular changes in interstitial lung diseases].
Flow cytometry (FC) usefulness for pulmonary reactive cell changes examination in interstitial lung diseases was assessed. Bronchoalveolar lavage (BAL) lymphocyte direct (two-color and three-color) phenotyping was carried out in 63 patients with sarcoidosis (subdivided according to the disease radiological stage and smoking status), 23 patients with systemic sclerosis (SSc) and 12 individuals exposed to silica dusts. 33 healthy volunteers were used as controls. Routine BAL cytology and peripheral blood lymphocyte (PBL) typing was performed in all tested subjects. ⋯ Summing up, the reference values for L-BAL subsets were proposed. CD4/CD8 ratio alterations in interstitial lung disorders should be interpreted as the local imbalance between T helper memory cells and sensitized T cytotoxic lymphocytes. FC characterization of alveolar lymphocytes provides insight into the pathogenesis of pulmonary diseases.
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Folia medica Cracoviensia · Jan 1997
Clinical Trial Controlled Clinical Trial[Evaluation of autonomic nervous system function with heart rate variability analysis in patients with hyperthyroidism and during euthyroidism after pharmacologic and surgical treatment].
The aim of the present study was both to estimate autonomic nervous system (ANS) function in patients with hyperthyroidism by the heart rate variability (HRV) analysis and to evaluate the impact of pharmacological and surgical treatment on the ANS function. Analysis of the HRV underwent 10 female patients in course of thyreotoxicosis and after reaching full clinical and biochemical euthyroidism, after pharmacological therapy and in month after surgical treatment. The 10 minutes records at rest, in horizontal position were evaluated. ⋯ On the base of the outcomes it was considered that in hyperthyroid patients there is advantage of sympathetic part of ANS over parasympathetic one which is due to sharp reduction of parasympathetic system activity. Pharmacological therapy with thyreostatics normalises balance of ANS to the level of the control group and after surgical treatment the balance keeps the same. Moreover, in the estimation of ANS as important as LF/HF ratio is the mean range of RR intervals.