Folia medica Cracoviensia
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Folia medica Cracoviensia · Jan 1997
Clinical Trial Controlled Clinical Trial[Use of flow cytometry in evaluation of cellular changes in interstitial lung diseases].
Flow cytometry (FC) usefulness for pulmonary reactive cell changes examination in interstitial lung diseases was assessed. Bronchoalveolar lavage (BAL) lymphocyte direct (two-color and three-color) phenotyping was carried out in 63 patients with sarcoidosis (subdivided according to the disease radiological stage and smoking status), 23 patients with systemic sclerosis (SSc) and 12 individuals exposed to silica dusts. 33 healthy volunteers were used as controls. Routine BAL cytology and peripheral blood lymphocyte (PBL) typing was performed in all tested subjects. ⋯ Summing up, the reference values for L-BAL subsets were proposed. CD4/CD8 ratio alterations in interstitial lung disorders should be interpreted as the local imbalance between T helper memory cells and sensitized T cytotoxic lymphocytes. FC characterization of alveolar lymphocytes provides insight into the pathogenesis of pulmonary diseases.
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Folia medica Cracoviensia · Jan 1997
Clinical Trial Controlled Clinical Trial[Evaluation of autonomic nervous system function with heart rate variability analysis in patients with hyperthyroidism and during euthyroidism after pharmacologic and surgical treatment].
The aim of the present study was both to estimate autonomic nervous system (ANS) function in patients with hyperthyroidism by the heart rate variability (HRV) analysis and to evaluate the impact of pharmacological and surgical treatment on the ANS function. Analysis of the HRV underwent 10 female patients in course of thyreotoxicosis and after reaching full clinical and biochemical euthyroidism, after pharmacological therapy and in month after surgical treatment. The 10 minutes records at rest, in horizontal position were evaluated. ⋯ On the base of the outcomes it was considered that in hyperthyroid patients there is advantage of sympathetic part of ANS over parasympathetic one which is due to sharp reduction of parasympathetic system activity. Pharmacological therapy with thyreostatics normalises balance of ANS to the level of the control group and after surgical treatment the balance keeps the same. Moreover, in the estimation of ANS as important as LF/HF ratio is the mean range of RR intervals.
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Folia medica Cracoviensia · Jan 1996
Clinical Trial[Diagnosis of interstitial lung disease (ILD) in patients with systemic sclerosis. The significance of broncho-alveolar lavage (BAL) --personal observations].
Review of current literature on pathogenesis and diagnostic approach to interstitial lung disease (ILD) in systemic sclerosis (SSc) was presented. The review focused in particular on the bronchoalveolar lavage (BAL). The experimental study was aimed to established whether early performed BAL is corresponding with clinical data, especially within a group with signs and symptoms of overt ILD. ⋯ Sensitivity of BAL in case of early ILD seems to be comparable with sensitivity of lung function tests (e.g. DLCO) and computerized tomography. The answer to the question which of the above mentioned methods in most appropriate to detect ILD risk in SSc remains unknown.
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Folia medica Cracoviensia · Jan 1993
Infant morbidity and mortality in a region of ecological disaster.
Infant morbidity and mortality in the Upper Silesian Industrial Region (USIR) are indices of ecological disaster. In the most polluted region of such towns as Bytom, Chorzów and Zabrze, the infant mortality rate is very high and increasing. ⋯ Most parents of children who died in the first year of life have been resident for at least 15 years. In Zabrze in recent years the percentage of congenital defects as the main cause of infant mortality is increasing.
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Folia medica Cracoviensia · Jan 1991
Review Comparative Study[Pathological processes with accumulation of fluid in the pericardial sac].
Fluid in the pericardial sac may accumulate due to transudate, inflammatory process in the pericardium, shunting of blood from the ventricles or large vessels into the pericardial cavity. The presence and amount of fluid is best evaluated by using echocardiography. Pathological fluid in the pericardial sac does not cause major hemodynamic disorders until the intrapericardial pressure is normal. ⋯ The patients complain of dyspnea and chest pain. Cardiac tamponade may be due to all causes of fluid accumulation in the pericardial sac, but most frequently it results from perforation or rupture of the left ventricle or aorta, and severe idiopathic, viral, uremic or neoplastic pericarditis. Therapy in cardiac tamponade consists of removal of the pericardial fluid by means of pericardiocentesis, pericardiotomy or pericardiectomy.