The Journal of burn care & rehabilitation
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J Burn Care Rehabil · Sep 1991
Effects of cimetidine on fluid requirement during resuscitation of third-degree burns.
Seventy percent body surface area third-degree burns were produced in four groups of six guinea pigs each, after which all were resuscitated with Ringer's lactate solution. Group 1 received 4 ml/kg/%burn. Group 2 received 1 ml/kg/%burn with cimetidine, which was begun at 0.5 hours after burn injury. ⋯ At 24 hours after burn injury, the water content of the burned skin of group 2 was significantly lower than that of the other groups. We conclude that in third-degree burns, cimetidine therapy can effectively reduce burn edema and the amount of required resuscitation fluid. Early administration is better than late administration of cimetidine.
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J Burn Care Rehabil · Sep 1991
Comparative StudyReperfusion injury in burned rats after delayed fluid resuscitation.
Organ failure from ischemic injury is common in deaths that are due to burn when fluid resuscitation is not performed. Organ perfusion after a delay in resuscitation, however, may induce or even accelerate ischemic organ damage. To study this phenomenon, 40 rats were classified (n = 10) to serve as normal control, burn with no resuscitation, burn with early fluid resuscitation, and burn with delayed resuscitation groups. ⋯ Water content of lung and muscle tissue were significantly lower (p less than 0.05) in the burn group that received no fluid resuscitation compared with that in early and delayed resuscitation groups. Water content of muscle was significantly greater with delayed resuscitation compared with the early resuscitation group. Results indicate that delayed fluid resuscitation in cases of burn shock may disrupt the cellular energy metabolism in some vital organs and cause skeletal muscle edema.(ABSTRACT TRUNCATED AT 250 WORDS)