The Journal of burn care & rehabilitation
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J Burn Care Rehabil · May 1996
Randomized Controlled Trial Comparative Study Clinical TrialDermasorb versus Jelonet in patients with burns skin graft donor sites.
A prospective and randomized trial that compares Jelonet (Smith & Nephew PLC, London, England) with a new hydrocolloid dressing, Dermasorb (Convatec Ltd., Clwyd, United Kingdom), is presented. The dressings were applied on contiguous donor sites in 21 patients that required skin grafting for burn wounds. Pain experienced with the dressing in situ was assessed on days 2, 4, 7, and on two subsequent occasions. ⋯ No clinical or laboratory evidence of any differences of colonization or infection were found. All results were statistically significant. We would strongly recommend the use of Dermasorb as a split-thickness skin graft donor site dressing for a patient with burns.
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Precise determination of burn depth during the immediate postburn period remains an unresolved clinical problem. In an attempt to provide a new clinical option to aid in diagnosis of burn depth, an immunohistochemical marker (antivimentin) was used to examine excisional tissues or serial punch biopsies, or both, in partial-thickness human burn injuries. To test the hypothesis that burn injury continues to progress beyond the first 24 hours, burn depth was assessed by quantitative morphometric analysis in both a partial-thickness porcine burn model and in sequential samples from human patients. ⋯ Similarly, 13 of 14 patients showed significant progression in burn depth between 1 to 5 days after burn injury. In conclusion, immunohistochemical staining with an antisera targeted toward a widely dispersed cell population in the dermis can be utilized as an effective tool to confirm the depth of tissue injury during the acute postburn period. Data from our randomly selected patients with partial-thickness burn suggest that burn wounds continue to demarcate for several days.
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J Burn Care Rehabil · May 1996
Case ReportsIntradermal injection of epinephrine to decrease blood loss during split-thickness skin grafting.
After a burn injury, the hemodynamics of a patient is changed. There is usually a fall in hematocrit. ⋯ The method we use to help decrease the loss of blood during skin grafting is an injection of epinephrine intradermally before the graft and eschar are excised. We have found this method to be useful in a select group of patients.
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J Burn Care Rehabil · May 1996
Reduced albumin extravasation in experimental rat skin and muscle burn injury by D-myo-inositol-1,2,6-trisphosphate treatment.
This study investigated the effects of the anti-inflammatory agent D-myo-inositol-1,2,6-trisphosphate (IP3) on burn edema. Two sets of experiments were performed. In the first set, a full-thickness burn injury was induced in the abdominal skin of anesthetized rats. ⋯ Resulted showed a significant reduction of albumin extravasation in the skin at all four dose levels and in the abdominal muscle at three of four doses. Indomethacin had no significant effect on postburn edema formation. The mechanisms responsible for the inhibition of albumin leakage by IP3 could be secondary to reduced formation of edema-promoting inflammatory mediators by the agent, resulting in improved vascular patency.