Läkartidningen
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Biography Historical Article
[Four surgeons introduced ether inhalation in Sweden. Then the anesthesiology was put to sleep for 100 years].
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Review Historical Article
[Oligodendrocytes have a key role in the development of CNS function and in myelin related diseases].
Oligodendrocytes provide CNS axons with myelin sheaths through processes of various lengths. The lipid-rich myelin insulates axons electrically, which increases conduction velocity. ⋯ A number of genetically manipulated animal models have provided insights regarding myelination and the function of myelin components. Current research on myelin related diseases, i.e. multiple sclerosis, focus on novel strategies for remyelination through transplantation of myelinating cells or stimulation of endogenous oligodendrocytes.
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The Scandinavian Neurotrauma Committee (SNC) was created by the Scandinavian Neurosurgical Society in order to develop evidence-based guidelines for improved care of neurotrauma patients. A MEDLINE search identified 475 papers dealing with the management of minimal, mild and moderate head injuries. Forty-two studies presenting Class II evidence on the initial management of such injuries were reviewed, and management guidelines were developed. ⋯ All patients with additional risk factors should be scanned and admitted. A flow-chart for clinical decision making and a Head Injury Instruction card is introduced. The SNC suggests guidelines that should be safe and cost-effective for the initial management of minimal, mild and moderate head injuries.