Prilozi / Makedonska akademija na naukite i umetnostite, Oddelenie za biološki i medicinski nauki = Contributions / Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences
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Recent anatomical and electrophysiological studies have demonstrated that in the human atrioventricular node there are two main extensions, the rightward and leftward posterior nodal extension (LPNE). The occurrence of eccentric retrograde atrial activation has been demonstrated in several previous reports to be from 6 to 8% in patients with AVNRT. ⋯ This study demonstrated the different electrophysiologic characteristics between the AVNRT patients with eccentric and concentric retrograde atrial activation. Standard ablation, but a little bit higher in the Koch's triangle, closer to the fast pathway, in the right atrium is effective and successful for AVNRT with retrograde left eccentric conduction in the coronary sinus.
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Imaging gene expression non-invasively and deep into opaque tissues has been a long-standing goal of molecular science. Optical gene reporters such as green fluorescent protein and luciferase have revolutionized cellular and molecular biology, however their in vivo application is limited, due to poor tissue penetration of visible light. ⋯ Ferritin has recently emerged as an MRI gene reporter for molecular applications, however its detection with MRI still has relatively low sensitivity. In this work we present an improved ferritin chimera, genetically engineered to exhibit stronger paramagnetic properties.
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Some rape cases result in the pregnancy of the victim and if the case is not reported to the police after the act with a subsequent gynaecological examination of the girl and the taking of a vaginal swab, there is no way of connecting the rape case with the perpetrator, except by parentage determination using DNA (deoxyribonucleic acid) analysis after abortion or induced delivery. In order to solve the rape case of a minor girl of 14 years which resulted with pregnancy, where a 60-year-old man was accused of the rape, DNA was extracted from blood samples from the girl and the putative assailant and from the foetus after its induced delivery. ⋯ A large number of identical loci between the mother's and the child's genotype led us to consider the possibility of incestuous paternity. Analysis of DNA samples from the girl's father and brother clarified the case as brother-sister incest.
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(Full text is available at http://www.manu.edu.mk/prilozi). Pulmonary arterial hypertension (PH) is predominantly a disease of young females. Yet, little is known regarding the effects of female sex hormones in PH. ⋯ This study provides the first evidence that in estrogen-deficient rats, progesterone has protective effects in MCT-induced PH. Further evaluation of the role of progesterone and its interaction with estrogens in pulmonary hypertension is warranted. Key words: Pulmonary Hypertension, Progesterone, Estrogens, Vascular remodeling.