British journal of obstetrics and gynaecology
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Br J Obstet Gynaecol · May 1977
Randomized Controlled Trial Clinical TrialEffect of bromocriptine on the premenstrual syndrome. A double-blind clinical trial.
Twenty-one patients suffering from the premenstrual syndrome were each studied during three menstrual cycles. After a control cycle, bromocriptine and placebo were given during the luteal phase of the cycle in a random double-blind cross-over manner, each patient serving as her own control. ⋯ Serum progesterone and oestradiol-17-beta were within normal ranges, and did not change during treatment. Medication considerably improved all the premenstrual symptoms, but mastodynia was the only one where bromocriptine was significantly better than the placebo.