British journal of obstetrics and gynaecology
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Br J Obstet Gynaecol · Jun 1994
Randomized Controlled Trial Clinical TrialLow dose aspirin in women with raised maternal serum alpha-fetoprotein and abnormal Doppler waveform patterns from the uteroplacental circulation.
To investigate the use of low dose aspirin in the reduction of perinatal morbidity and mortality in women with unexplained raised maternal serum alpha-fetoprotein and abnormal uteroplacental Doppler waveform patterns. ⋯ This trial revealed a benefit of low dose aspirin therapy in women with raised maternal serum alpha-fetoprotein and abnormal uteroplacental Doppler waveform patterns, but the effect was smaller than expected. Although a reduction in deaths from small preterm babies was observed, there was an increase in the number of deaths following placental abruption without a significant increase in the number of abruptions. We recommend that this should be considered before giving aspirin to these high risk women and that other investigators should specifically look for this effect.
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Br J Obstet Gynaecol · Jun 1994
Serum CA 125 levels and sonography in the pre-operative assessment of myometrial invasion of endometrial cancer.
To assess the value of elevated serum CA 125 levels and ultrasonography in predicting deep myometrial invasion of endometrial cancer. ⋯ Ultrasonography was more accurate than serum CA 125 levels in predicting myometrial invasion of endometrial carcinoma.