Nihon rinsho. Japanese journal of clinical medicine
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The human coronavirus (HCoV) contains HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV- HKU1, SARS-CoV and MERS-CoV. HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1 are pathogens of common cold. During 2002-2003, a new coronavirus, the SARS-CoV, was found to be the cause of an acute, severe frequently fatal respiratory disease with prominent systemic symptoms (severe acute respiratory syndrome). ⋯ This novel coronavirus has been named Middle East respiratory syndrome coronavirus (MERS-CoV). The virus probably has come from camels and bats. I describe here about coronaviruses that have wide disease spectrum.from common colds to severe fatal illness as emerging infectious diseases.
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Bronchial thermoplasty(BT) is a novel therapeutic modality for adult patients with severe asthma. BT is a procedure of applying radio frequency thermal energy to the airways with the goal of ablating the airway smooth muscle and ameliorating airway hypersensitivity. ⋯ BT was introduced in Japan on April 2015, and the number of treated asthma patients is increasing. In this article, we describe the methods, effectiveness, safety and the current status of BT in Japan.
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Association of rheumatoid arthritis (RA) with bronchiectasis (BR) has attracted rising attention recently. Prevalence of BR in patients with RA was higher compared to general population and so was prevalence of RA in patients with BR. ⋯ Histological analysis of biopsied pulmonary tissue from patients with RA showed that inducible bronchus-associated lymphoid tissue (iBALT) contained a larger number of lymphoid follicles and germinal centers, and produced RAAAB. These data indicate that lung can be a primary initiating site of autoimmunity in RA.