Nihon rinsho. Japanese journal of clinical medicine
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It is well known that diabetes often induces macrovascular and microvascular complications, and hypertension is also considered to be an important risk factor for macrovascular events. Recent epidemiological studies have proved the possibility that hypertension among patients with diabetes greatly increases the risks of these complications. ⋯ Co-existent metabolic risk factors such as hyperlipidemia rather than hypertension may affect more coronary heart disease. Antihypertensive treatment among diabetic patients is expected to reduce various complications, but management of metabolic risk factors is also needed to prevent coronary heart disease.
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Nausea and vomiting are the most distressing side effects reported by patients undergoing CDDP-based cancer chemotherapy. Dopamine receptor antagonists and corticosteroids are used as anti-emetics for chemotherapy induced nausea and vomiting. Recently, a highly selective 5-HT3 receptor antagonist are proved to demonstrate antiemetic activity. 5-HT3 receptor antagonists are developed such as Granisetron, Ondansetron, Ramosetron, Azasetron. ⋯ Though, it is reported to be only 20% effective for the complete control of delayed emesis. Psychiatric medications sometimes play a prominent role in the control of persisting emesis, particularly anticipatory or conditioned nausea. Nausea and vomiting are well controlled using various anti-emetics considering patient's condition and chemotherapy schedule.
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In contrast to conventional assumption that myocytes are never renewed after birth, a growing body of evidence suggests that human cardiac myocytes might divide in myocardial infarction and severe heart failure. Bone marrow cells may also contribute to myocyte regeneration, when injected or mobilized into systemic circulation by cytokines. ⋯ No adverse effect was found. Cell therapy using adult stem cells is anticipated to be an effective treatment of heart failure.
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Review Case Reports
[Perioperative management of patients with idiopathic thrombocytopenic purpura].
Patients suffering from idiopathic thrombocytopenic purpura(ITP) who undergo surgery may have an increased risk of postoperative bleeding complications. In general, bleeding is a regular occurrence when the platelet count is less than 30,000 to 50,000/mm3. ⋯ No difficulty was encountered with hemostasis and the postoperative course was uneventful in all 3 patients. In patients with ITP, adequate perioperative management, such as high-dose immunoglobulin and platelet transfusion allows surgical treatment to be performed safely and successfully.