Connecticut medicine
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Connecticut medicine · Apr 1990
Case ReportsThe electrocardiographic changes in a case of flecainide overdose.
Flecainide acetate is a new potent class I antiarrhythmic agent. We report serial electrocardiographic changes occurring in a case of flecainide overdose. ⋯ The prolonged electrocardiographic time intervals (PR and QRS) decreased in correlation with falling drug levels. As the case was associated with concomitant alcohol intoxication, we speculate about the protective effect of alcohol in order to explain our patient's benign clinical course.
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Heparin-induced thrombocytopenia and thrombosis can occur with both low-dose and high-dose heparin. Clinicians should be aware of this syndrome, and platelet counts should be monitored prior to initiating heparin and during the course of therapy. The treatment of heparin-induced thrombocytopenia is variable depending on the use of heparin in each individual patient. ⋯ Aspirin given with dipyridamole or Iloprost have both been reported to be successful in managing this group of patients. Heparin is a commonly used drug in all areas of medicine. The early recognition and treatment of heparin-induced thrombocytopenia and thrombosis has resulted in a reduction in the morbidity associated with this syndrome.