Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2006
[Effects of mild hypothermia on expression of N-methyl-D-aspartate receptor-1 in hippocampus neurons after cardiopulmonary resuscitation in rats].
To explore the effects of mild hypothermia on expression of N-methyl-D-aspartate receptor-1 (NMDAR1) in hippocampus neurons after cardiopulmonary resuscitation (CPR) in rats. ⋯ Mild hypothermia can down regulate the expression of NMDAR1 mRNA and protein level, lower positive ion concentration and thus decrease cerebral edema, so mild hypothermia can serve as a treatment measure for cerebral edema after CPR.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2006
[Study on safety of apnea test in clinical determination of brain death].
To determine the occurrence of severe complications such as hypotension, pulmonary artery hypertension as well as hypercapnia during apnea test in the affirmation of brain death and to investigate the possible effective prophylactic interventions. ⋯ Adequate oxygenation could be maintained during conventional apnea test. The risk of inducing severe hypotension is low in non brain death patients. Based on adequate preload, low dose of NE infusion could prevent patients with high risk circulation instability from severe hypotension.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2006
[Changes in cerebral oxygen metabolism and significance in patients with severe head injury].
To investigate the changes in cerebral oxygen metabolism following head injury and their relationship with intracranial pressure (ICP), cerebral perfusion pressure (CPP), and Glasgow coma scale (GCS). ⋯ In patients with serious head injury, if the increase in ICP is mild or moderate, there are cerebral hypoxia and ischemia during the first 24 hours after injury. During the 2 nd-4 th postinjury days, the brain becomes hyperemic and hyperoxygenated. Marked increase in ICP results in persistent cerebral hypoxia and ischemia. ICP, CPP and GCS score are main factors affecting cerebral oxygen metabolism.