Journal of toxicology. Clinical toxicology
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In the Pacific Northwest region of the US and in southwestern British Columbia, Canada, isolated cases of renal failure have occurred following ingestion of wild mushrooms. We report four cases in which toxic mushrooms were mistaken for the edible pine mushroom or matsutake (Tricholoma magnivelare). ⋯ Mushroom field guides warn against mistaking Amanita smithiana for pine mushrooms. They are similar in size, color and habitat. It appears possible that Amanita smithiana mushrooms were eaten instead of pine mushrooms in these cases.
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J. Toxicol. Clin. Toxicol. · Jan 1997
Multicenter StudyProspective multicenter evaluation of tramadol exposure.
Tramadol is a novel analgesic possessing both opiate and noradrenergic effects. Its low potential for abuse suggests increasing use, but there are limited data on the toxicity in overdose. ⋯ This study suggests significant neurologic toxicity from tramadol overdose. Serious cardiovascular toxicity was not seen.
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J. Toxicol. Clin. Toxicol. · Jan 1997
Experimental studies of methemoglobinemia due to percutaneous absorption of sodium nitrite.
Methemoglobin formation caused by a liniment solution containing sodium nitrite (30 g/L and 140 g/L) was studied in rats with normal or abraded skin, by measuring the methemoglobin concentration before and after application of liniment solutions with differing nitrite concentration. ⋯ Each of these findings are characteristic of nitrite and they imply the percutaneous absorption of nitrite. Regardless of the nitrite concentration, the methemoglobin concentration was consistently higher in abraded skin than in normal skin.
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J. Toxicol. Clin. Toxicol. · Jan 1997
Historical ArticleAnaleptic use in clinical toxicology: a historical appraisal.
The introduction and increasing popularity of the barbiturates during the first two decades of the 20th century was associated with a new life threatening toxicological problem: the barbiturate overdose. ⋯ Although barbiturate overdose mortality decreased to less than 1% using this strategy, it would take another 20 years before this technique was universally adapted. While analeptic therapies for the treatment of drug overdose have now been abandoned, one of these analeptics, methylphenidate, currently enjoys wide use in the treatment of attention deficit hyperactivity disorder.