Journal of toxicology. Clinical toxicology
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J. Toxicol. Clin. Toxicol. · Jan 1996
Five year retrospective evaluation of sulfonylurea ingestion in children.
Oral hypoglycemic medications are frequently used for Type II diabetes and accidental ingestions by children may occur. There are no comprehensive pediatric studies documenting poison center experiences. ⋯ Children ingesting oral hypoglycemics should be admitted to a health care facility for 24 h observation. In this series a single tablet produced hypoglycemia.
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J. Toxicol. Clin. Toxicol. · Jan 1996
Case ReportsDelayed peak serum valproic acid in massive divalproex overdose--treatment with charcoal hemoperfusion.
Increased clearance and apparent clinical improvement in valproic acid overdose has been reported following in-series hemodialysis/hemoperfusion therapy. We report a case of divalproex sodium and chlorpheniramine overdose treated with charcoal hemoperfusion and multiple-dose activated charcoal. ⋯ Enteric coated valproic acid preparations may cause delayed toxicity in overdose, particularly with coingested anticholinergic medications. In our case, charcoal hemoperfusion appeared to increase valproic acid clearance.
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J. Toxicol. Clin. Toxicol. · Jan 1996
The effect of hypertonic sodium bicarbonate on QRS duration in rats poisoned with chloroquine.
To determine efficacy of hypertonic sodium bicarbonate in narrowing QRS prolongation produced by chloroquine. ⋯ Hypertonic sodium bicarbonate partially reversed sodium channel blockade and resultant QRS interval prolongation produced by chloroquine in rats. These data should be interpreted with caution, given the need to extrapolate to humans and the modest effect of sodium bicarbonate on QRS narrowing.
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J. Toxicol. Clin. Toxicol. · Jan 1995
Case ReportsLiver transplantation after severe poisoning due to amatoxin-containing Lepiota--report of three cases.
Four cases of severe Lepiota poisoning, including three which developed toxic fulminant hepatitis treated by orthotopic hepatic transplantation, are reported here. The toxicity of the Lepiota is discussed as well as the indications for hepatic transplantation in poisonings due to amatoxin-containing mushrooms.
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J. Toxicol. Clin. Toxicol. · Jan 1995
Case ReportsProlonged neuromuscular blockade when mivacurium and pancuronium were administered in series.
Long acting non-depolarizing neuromuscular blockade is useful in many clinical circumstances, especially during surgical procedures. Reinstitution of the blockade for short periods to facilitate the completion of clinical tasks can be accomplished in different ways. We present a case wherein a short-acting non-depolarizing neuromuscular blocker used after a long-acting one resulted in an unusual prolongation of the neuromuscular blockade.