Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Jan 2020
ReviewMicroRNAs in the development of left ventricular remodeling and postmyocardial infarction heart failure.
Acute myocardial infarction (AMI) induces unfavorable left ventricular remodeling (LVR), a complex process that involves molecular, cellular, and geometric alterations leading to important changes in heart structure and function. Heart failure (HF) is a frequent complication of AMI, and it remains a serious clinical, epidemiological, and economic challenge. Despite advances in the therapy and management of HF, many patients still suffer from severe symptoms. ⋯ Moreover, the significance of circulating miRNAs as noninvasive prognostic biomarkers in the prediction of LVR and HF after AMI has also been discussed. In conclusion, miR‑29 family members (miR‑29a and miR‑29b), miR‑150, and miR‑30a‑5p represent different groups of miRNAs, but all of them are involved in the regulation of the fundamental processes associated with post‑AMI left ventricular dysfunction and HF. Furthermore, these miRNA molecules may serve as a potential therapeutic target during disease progression.
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Pol. Arch. Med. Wewn. · Jan 2020
ReviewMolecular epidemiology of SARS CoV-2: a review of current data on genetic variability of the virus.
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), associated with coronavirus disease 2019 (COVID‑19), is a novel pathogen recently introduced to the human population. It is characterized by rapid epidemic transmissions due to lack of herd immunity as well as by notable mortality which increases with age and in patients with comorbidities. Outbreak forecasting and modelling suggest that the number of infected people will continue to rise globally in the forthcoming months. ⋯ It is unknown if this difference is associated with a higher virulence of viral strains, differences in host genomics, access to medical resources, or other unknown variables. Little is also known about SARS‑CoV‑2 evolutionary and transmission patterns as a limited number of large‑scale sequence and phylogenetic analyses have been performed so far. In this review, we aimed to provide concise data on the SARS‑CoV‑2 genomics, molecular evolution, and variability with special consideration of the disease course.