Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Aug 2022
SARS-CoV-2 vaccination in liver transplant recipients: factors affecting immune response and refusal to vaccine.
The effectiveness of SARS‑CoV‑2 vaccination in liver transplant (LT) recipients varies between reports. ⋯ The lower immune response in the vaccinated LT recipients than in the general population justifies administering the third dose of the vaccine. However, more data are needed to recommend any therapy modification before the vaccination.
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Pol. Arch. Med. Wewn. · Aug 2022
ReviewSurviving Sepsis Campaign Guidelines 2021: highlights for the practicing clinician.
The 2021 Surviving Sepsis Campaign Guidelines provided evidence-based recommendations for adult patients with sepsis and septic shock. This iteration of the guidelines placed increased emphasis on a diverse, global perspective, as well as on the long-term sequelae of sepsis experienced by patients and their families. ⋯ In this review, we provide a summary of key recommendations of interest to the practicing clinician, which are either novel or require a change in practice, as well as those for which the evidence has substantially evolved in the 5 years since the 2016 iteration of the Guidelines. Rather than reviewing the underlying evidence, we emphasize the practical aspects of interpretation, dissemination, and implementation of these recommendations in the clinical setting.
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Pol. Arch. Med. Wewn. · Aug 2022
ReviewMolecular cytogenetics in acute myeloid leukemia in adult patients: practical implications.
Throughout the last 50 years, cytogenetic analyses of pretreatment bone marrow and / or blood samples from patients diagnosed with acute myeloid leukemia (AML) revealed a large number of recurring chromosome aberrations, both structural and numerical. Using standard banding methods and, more recently, molecular cytogenetic techniques, such as fluorescence in situ hybridization, spectral karyotyping, multiplex fluorescence in situ hybridization and comparative genomic hybridization, cytogenetic investigations detect acquired abnormalities that, together with submicroscopic gene mutations and changes in gene expression, strongly influence the clinical features and prognosis of patients with AML. ⋯ Such classifications divide patients into broad prognostic categories: favorable, intermediate, and adverse, which are useful in the management of adults with AML. In this article, I review the present data on recurrent chromosome rearrangements in AML and on correlations between cytogenetic findings and clinical features and treatment outcomes of adult patients diagnosed with AML.
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Pol. Arch. Med. Wewn. · Aug 2022
The relationship between subclinical depressive symptoms and metabolic parameters in women: a subanalysis of a Bialystok PLUS study.
Clinically overt depression is associated with an increased risk for insulin resistance. Data regarding the impact of subclinical depressive symptoms on the risk of diabetes are limited. ⋯ Subclinical depressive symptoms in women might predispose to dysglycemia.
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Pol. Arch. Med. Wewn. · Aug 2022
Biologic treatment of inflammatory bowel disease in Poland, 2012-2020: nationwide data.
The frequency of biologic drug treatment for Polish patients diagnosed with ulcerative colitis (UC) or Crohn disease (CD) has been insufficiently studied. ⋯ We showed a growing use of biologic agents in the treatment of IBD in Poland. Womenreceive biologic treatment for IBD significantly less frequently than men. The pediatric population features the highest proportion of patients receiving such treatment.