Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Oct 2019
Comparative StudyImmunosuppressive treatment with everolimus in patients after liver transplant: 4 years of single-center experience.
Everolimus after liver transplant (LT) has been used to minimize the use of calcineurin inhibitors (CNIs), optimize renal function, and prevent recurre nce of hepatocellular carcinoma (HCC). ⋯ This study showed that switching from CNIs to everolimus after LT allowed a safe weaning of CNIs and an improvement in creatinine levels. In patients on everolimus monotherapy, we observed dyslipidemia as a dose‑dependent side effect of the drug as well as a lower risk of HCC recurrence.
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Pol. Arch. Med. Wewn. · Oct 2019
Paper-based training diaries for monitoring of performance progress due to long-term physical activity.
Training diaries are a common tool for training monitoring; however, their correlation with an effective performance gain is unclear. ⋯ Paper-based training diaries might serve as an additional tool in the monitoring of training progress. However, because of the discrepancy between reported training loads and objectively measured training progress, they are not suitable to replace a standard bicycle stress test for an exact determination of performance gain in hobby athletes. New devices, such as fitness trackers or watches, may present better alternatives in the future.
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Pol. Arch. Med. Wewn. · Oct 2019
Predictors of appropriate interventions and mortality in patients with implantable cardioverter-defibrillators.
Additional risk assessment in patients with heart failure referred for implantable cardioverter‑defibrillator (ICD) implantation as primary prevention is needed. A reduction in left ventricular ejection fraction (LVEF) seems to lack sufficient sensitivity and specificity to be used for identification of patients at the highest risk of sudden cardiac death. ⋯ Implantation of ICD or CRT‑D as secondary prevention was a potent predictor of appropriate intervention, while resynchronization therapy and severe mitral regurgitation predicted ICD therapy in primary prevention. In patients with ICD or CRT-D, independent predictors of mortality included: body mass index, hemoglobin concentrations, LVEF, diabetes, and left atrial diameter.
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Pol. Arch. Med. Wewn. · Oct 2019
Prognostic value of midregional proadrenomedullin in critically ill patients.
Scoring systems can be used to predict the risk of mortality and outcomes in critically ill patients. Acute kidney injury (AKI) is one of the strongest factors negatively influencing patient outcomes. Midregional proadrenomedullin (MR‑proADM) shows promising results as an outcome predictor in patients with sepsis. ⋯ MR‑proADM can be applied in clinical practice as a prognostic tool for mortality but not incident AKI in the general ICU population with at least similar accuracy as APACHE II and SOFA scores.