Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Dec 2018
LetterA novel CCK2/gastrin receptor-localizing radiolabeled peptide probe for personalized diagnosis and therapy of patients with progressive or metastatic medullary thyroid carcinoma: a multicenter phase I GRAN-T-MTC study.
Abstract
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Pol. Arch. Med. Wewn. · Nov 2018
Prevalence of high on-treatment platelet reactivity in patients with chronic kidney disease treated with acetylsalicylic acid for stroke prevention.
Introduction Chronic kidney disease (CKD) is one of risk factors for stroke and may be associated with impaired platelet reactivity. Objectives The aim of the study was to evaluate platelet reactivity in patients with CKD treated with acetylsalicylic acid (ASA), using 2 different laboratory methods. Moreover, we searched for factors responsible for the phenomenon of high on-treatment platelet reactivity (HOPR). ⋯ Conclusions The applied methods allowed to detect HOPR in more than one third of CKD patients taking ASA for stroke prevention. The compatibility of both methods for HOPR assessment was confirmed. The study revealed several potential risk factors for HOPR in CKD, including younger age, higher levels of inflammatory markers, dyslipidemia, and lower hematocrit and hemoglobin levels.
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Pol. Arch. Med. Wewn. · Aug 2018
ReviewLung cancer in chronic obstructive pulmonary disease patients: importance of cellular senescence.
Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of lung cancer, independently of smoking, although the link between these diseases remains unknown. Possible pathophysiologic mechanisms include inflammation and cellular senescence. ⋯ Previous studies have confirmed the significant role of cellular senescence in the development of various tumors, including lung cancer. It is highly probable that cellular senescence contributes to carcinogenesis in COPD patients.