British medical journal (Clinical research ed.)
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Br Med J (Clin Res Ed) · Feb 1987
Randomized Controlled Trial Comparative Study Clinical TrialPropofol infusion for sedation in the intensive care unit: preliminary report.
Propofol (2,6,di-isopropylphenol) was given by continuous intravenous infusion to provide sedation after cardiac surgery in 30 patients and its effects compared with those of midazolam given to a further 30 patients. Propofol infusion allowed rapid and accurate control of the level of sedation, which was satisfactory for longer than with midazolam. ⋯ Both medical and nursing staff considered the propofol infusion to be superior to midazolam in these patients. These findings suggest that propofol is a suitable replacement for etomidate and alphaxalone-alphadolone for sedating patients receiving intensive care.