Annals of the American Thoracic Society
The most recent articles from:
Ann Am Thorac Soc
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Editorial Comment
Untangling Health Trajectories among Patients with Sepsis.
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Randomized Controlled Trial
Trazodone Effects on Obstructive Sleep Apnea and Non-REM Arousal Threshold.
A low respiratory arousal threshold is a physiological trait involved in obstructive sleep apnea (OSA) pathogenesis. Trazodone may increase arousal threshold without compromising upper airway muscles, which should improve OSA. ⋯ These findings suggest that trazodone could be effective therapy for patients with OSA without worsening hypoxemia. Future studies should focus on underlying mechanisms and combination therapies to eliminate OSA. Clinical trial registered with www.clinicaltrials.gov (NCT 01817907).