Radiology
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To evaluate whether diffusion-tensor imaging can be combined with double inversion recovery to improve the detection of structural changes occurring in the cortex of patients with multiple sclerosis (MS). ⋯ Compared with control subjects, patients with RRMS had an increase in FA of NAGM that strongly correlated with cortical lesion volume and clinical disability.
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Diffusion-weighted (DW) magnetic resonance (MR) imaging is emerging as a powerful clinical tool for directing the care of patients with cancer. Whole-body DW imaging is almost at the stage where it can enter widespread clinical investigations, because the technology is stable and protocols can be implemented for the majority of modern MR imaging systems. ⋯ Because whole-body DW imaging excels at bone marrow assessments at diagnosis and for therapy response, it can potentially address a number of unmet clinical and pharmaceutical requirements. There are compelling needs to document and understand how common and novel treatments affect whole-body DW imaging results and to establish response criteria that can be tested in prospective clinical studies that incorporate measures of patient benefit.
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To explore the role of histogram analysis of apparent diffusion coefficient (ADC) maps based on entire tumor volume data in determining glioma grade and to evaluate the diagnostic performance of ADC maps at standard (1000 sec/mm(2)) and high (3000 sec/mm(2)) b values. ⋯ Histogram analysis of ADC maps based on entire tumor volume can be a useful tool for grading gliomas. The fifth percentile of the cumulative ADC histogram obtained at a high b value was the most promising parameter for differentiating high- from low-grade gliomas.
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To evaluate the image quality and clinical utility of a polytrauma computed tomographic (CT) protocol that integrates lower extremity CT angiography into multiphasic whole-body trauma CT by utilizing 64-detector CT and a single contrast material bolus. ⋯ Integration of lower extremity CT angiography into multiphasic whole-body trauma imaging is feasible, helps detect clinically relevant vascular injuries, and results in diagnostic image quality in the majority of patients.