Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
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Pol. Merkur. Lekarski · Jul 2003
Review[Potential role of environmental and occupational pollutants in the etiological pathogenesis of idiopathic pulmonary fibrosis].
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually fatal lung disease of no identifiable etiology, which is characterised by fibroblast proliferation and extracellular matrix accumulation resulting in irreversible distortion of the architecture of the lung. Some studies suggest the role of various environmental exposure and occupational pollutants in the etiopathogenesis of IPF. ⋯ This article is a review of studies searching for potential etiological factors of IPF in the environment in the place of living and place of working. It seems, that conflicting results of these studies make impossible to determine the potential role of environmental and occupational pollutants in the pathogenesis of IPF.
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Pol. Merkur. Lekarski · Jul 2003
[Gabapentin in the treatment of neuropathic pain in patients with type 2 diabetes mellitus].
Assessment of pain relief in type 2 diabetes mellitus patients with neuropathic pain treated with gabapentin at daily dose 2400 mg. ⋯ The neurophysiological examinations carried out in the patients with sensory neuropathy demonstrated a significant conduction impairment in sensory and motor nerves as well as in sympathetic sweat-secreting nerves. After six weeks of gabapentin treatment in 2400 mg daily dose a significant pain reduction was observed, assessed by means of SF-MPQ, VAS and PPI questionnaires. The authors have demonstrated a significant analgesic effect of gabapentin in patients with diabetic neuropathy and the suggest administration of this preparation in chronic diabetic neuropathy in order to improve the quality of patients' life.