Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
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Pol. Merkur. Lekarski · Jan 2008
Case Reports[Pyoderma gangrenosum--an interdisciplinary diagnostic problem].
Pyoderma gangrenosum is a rare, chronic, progressive and noninfectious necrosis of skin with an unclear etiology. It usually coexists with the systemic disorders. Clinically it appears as a rapidly spreading ulceration in a various location. ⋯ Due to the presumptive diagnosis of phlegmon of the patient's right arm she was initially admitted to surgical ward. Sometimes there are many difficulties with an early diagnosis of pyoderma gangrenosum because of its rarity, distinctness of clinical pictures, lack of characteristic histology and laboratory tests. We would like to emphasize that pyoderma gangrenosum should be always included to the differential diagnosis of a rapidly progressing ulceration of skin especially if there is no response to standard therapy.
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Acromegaly is a slow developing chronic debilitating disease caused by a growth hormone (GH)-producing pituitary adenoma. The clinical consequences of acromegaly result both from excess GH secretion and from mass effect of the pituitary tumour. The disease is associated with increased morbidity and mortality compared to normal population. ⋯ All these forms of treatment attempt to control the disease by reducing GH secretion from the tumour and inhibiting the growth of adenoma. The decision concerning the choice of therapy should depend on age, the severity of acromegaly and the presence of its complications and should also consider the dangers associated with each treatment. This review paper summarizes the contemporary treatment of acromegaly with special emphasis on their established benefits and risks.