Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
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Pol. Merkur. Lekarski · Nov 2012
Review[Possibilities of therapeutic intervention in severe infections].
Severe infections of the respiratory system are the most important causes of hospital mortality and often unfold as severe sepsis or septic shock. Systemic inflammatory response syndrome (SIRS) with infection evidence (known as sepsis) and septic shock (severe sepsis with hemodynamic instability relentless on fluid resuscitation) are major healthcare problems, affecting millions of individuals around the world and killing about one-third affected every year. Similarly to myocardial infarction or severe trauma rapid onset and appropriateness of medical management in the first hours of sepsis are key point for clinical outcome.
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Fungal infections are becoming more common causes of respiratory disease, since most species of pathogenic fungi occurring in Europe are responsible for developing opportunistic infections. Most cases of fungal infections of the respiratory system are caused by a species commonly encountered in the environment or colonizing saprophytic species such as the gastrointestinal tract. Some recognition of fungal diseases can be determined on the basis of: breeding material taken from the affected places, or blood, or microscopic histopathology. In the treatment of fungal infections of the respiratory system are currently used 3 classes of antifungal drugs: antifungal polyene antibiotics, triazoles and echinocandines.