Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
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Pol. Merkur. Lekarski · Jan 2013
Randomized Controlled Trial[The relationship between testosterone deficiency and metabolic syndrome in obese men].
In aging males testosterone decreases approximately 0,8-1% annually. This physiological process can be intensified in obesity and metabolic syndrome (MS). Progressive testosterone deficiency can exacerbate existing metabolic disorders, leading to a vicious circle. The aim of the study was to assess the frequency of testosterone deficiency syndrome (TDS) and concomitance of TDS and MS in obese male patients. Moreover assessment of correlation between TDS markers (total testosterone - TT, free testosterone - fT, sex-hormone binding globulin - SHBG) and obesity, blood pressure, fasting lipid levels, fasting blood glucose, high-sensitivity C-reactive protein (hsCRP), fibrynogen (Fb) was performed. The present study aimed to establish if patients with TDS and MS have more severe metabolic disorders, higher average systolic and diastolic pressure comparing to group with MS without TDS. ⋯ Among obese males aged > or = 39 frequency of TDS is high (47%). Coincidence of MS and TDS was observed in 56% patients. The inverse correlation between body weight and SHBG and TT was noted and positive association between SHBG and age was established in MS(+) group. No statistically significant difference in fasting lipid levels, fasting blood glucose, CRP, Fb, BP was found between MS(+)TDS(+) patients and MS(+)TDS(-). No statistically significant correlation was found between TT fT, SHBG and IIEF-5, AMS score.