Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
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Pol. Merkur. Lekarski · Sep 2018
Editorial Review[The role of high cut off membranes in renal replacement therapy of acute kidney injury in the course of sepsis - the current state of knowledge].
Sepsis as a systemic inflammatory reaction to infection is an important interdisciplinary clinical problem. Over the past 20 years, the number of patients who have contracted sepsis has doubled. The occurrence of acute kidney injury in the course of sepsis increases mortality twice, while chronic kidney disease develops in 50% of the patients who survived sepsis. ⋯ The basis for the implementation of this type of treatment was the "maximum concentration" hypothesis, which assumes that, avoiding the onset of the early peak of circulating proinflammatory molecules is possible to prevent and modulate the clinical effects of an excessively expressed inflammatory reaction in the course of sepsis. This study is an attempt to analyze and summarize the current state of knowledge on the effectiveness of using HCO membranes in patients with sepsis who have developed AKI. For this purpose, the resources of MEDLAIN/Pubmed bases from 1965 to April 2018 have been analyzed, taking into account only the full versions of articles in English, using a combination of the following words: super high-flux, high cut-off, dialysis, renal replacement therapy, filtration, diafiltration, hemodialysis, hemofiltration, hemodiafiltration, sepsis, cytokine, inflammatory mediators, inflammation.