European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Jan 2014
Randomized Controlled TrialComparison of unilateral spinal anesthesia and L₁ paravertebral block combined with psoas compartment and sciatic nerve block in patients to undergo partial hip prosthesis.
Just as hip prosthesis, most of the patients undergoing orthopedic lower extremity surgery (OLES) belong to the advanced age group. Sciatic nerve block combined with psoas compartment block is used as a technique alternative to central neuraxial block and GA. In geriatric patients that will undergo partial hip prosthesis, the effects of the methods of unilateral spinal anesthesia (SA) and L1 paravertebral block combined with psoas compartment block (PCB) and sciatic nerve block (PCSL) on peroperative hemodynamic parameters and the duration of need for postoperative analgesia were studied. ⋯ Unilateral SA conducted with bupivacaine hydrochloride and PCSL block technique provided a hemodynamically similar activity in the perioperative period in patients that underwent partial hip operation. However, PCSL block implementation extended the initial time of the need for analgesia in postoperative period. PCSL method could be selected in cases belonging to such group of patients. PCSL block can be a alternative anesthetic tecniques in patients that underwent partial hip operation.
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Eur Rev Med Pharmacol Sci · Jan 2014
The cyclic hexapeptide AcF attenuates sepsis-induced acute lung injury and mortality in rats.
The purpose of this study was to elucidate the possible beneficial effects of AcF on acute lung injury (ALI) in a rat model of sepsis. ⋯ AcF administration ameliorates acute lung injury in a rat model of sepsis induced by CLP. AcF can be developed as a novel treatment for severe sepsis-induced ALI.
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Eur Rev Med Pharmacol Sci · Jan 2014
Study on plasmatic metabolomics of Uygur patients with essential hypertension based on nuclear magnetic resonance technique.
Metabolomics is the analysis of the global constitution of endogenous metabolites in cells, tissue, and bodily fluids based on analysis techniques with high output, high sensitivity, and high resolution. The physiological and pathological state of the subject investigated could be identified and analyzed through examining metabolite changes. In this study, 1H-NMR metabolomics was employed to study plasma metabolites of both Uygur patients with hypertension and healthy people, thereby filtering out characteristic metabolites for Uygur patients with hypertension. The pathogenesis of hypertension was discussed via metabolic pathways. ⋯ The 1H-NMR metabolomics process, in combination with OPLS-DA pattern identification, is an effective way to differentiate the serum metabolites characteristic of hypertension patients. Pattern identification analysis of NMR spectrum data with OPLS-DA could identify metabolites of hypertension patients versus healthy subjects. The metabolic phenotype of Uygur hypertension patients shows significant heteromorphosis, with the 12 characteristic metabolites as potential biomarkers of hypertension.
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Eur Rev Med Pharmacol Sci · Jan 2014
Case ReportsTwo cases of Brown-Séquard syndrome in penetrating spinal cord injuries.
Brown-Séquard syndrome due to a stab injuries is uncommon and results from a lesion in one half of the spinal cord. ⋯ As the neurologic improvement depends on the type and severity of the spinal cord damage, the indications for acute surgical management are limited and conservative management should be preferred.
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Eur Rev Med Pharmacol Sci · Jan 2014
Randomized Controlled TrialThe relationship between blood lactate, carboxy-hemoglobin and clinical status in CO poisoning.
We aimed to determine the relationship between blood lactate, carboxy-hemoglobin (COHb) levels and the severity of clinical findings in patients with CO poisoning. ⋯ According to our study, blood lactate and COHb levels were both correlated with the changes of consciousness in CO poisoning. Blood lactate levels together with COHb in defining indications for HBO treatment might be suggested.