European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Jan 2014
Study on plasmatic metabolomics of Uygur patients with essential hypertension based on nuclear magnetic resonance technique.
Metabolomics is the analysis of the global constitution of endogenous metabolites in cells, tissue, and bodily fluids based on analysis techniques with high output, high sensitivity, and high resolution. The physiological and pathological state of the subject investigated could be identified and analyzed through examining metabolite changes. In this study, 1H-NMR metabolomics was employed to study plasma metabolites of both Uygur patients with hypertension and healthy people, thereby filtering out characteristic metabolites for Uygur patients with hypertension. The pathogenesis of hypertension was discussed via metabolic pathways. ⋯ The 1H-NMR metabolomics process, in combination with OPLS-DA pattern identification, is an effective way to differentiate the serum metabolites characteristic of hypertension patients. Pattern identification analysis of NMR spectrum data with OPLS-DA could identify metabolites of hypertension patients versus healthy subjects. The metabolic phenotype of Uygur hypertension patients shows significant heteromorphosis, with the 12 characteristic metabolites as potential biomarkers of hypertension.
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Eur Rev Med Pharmacol Sci · Jan 2014
Randomized Controlled TrialThe relationship between blood lactate, carboxy-hemoglobin and clinical status in CO poisoning.
We aimed to determine the relationship between blood lactate, carboxy-hemoglobin (COHb) levels and the severity of clinical findings in patients with CO poisoning. ⋯ According to our study, blood lactate and COHb levels were both correlated with the changes of consciousness in CO poisoning. Blood lactate levels together with COHb in defining indications for HBO treatment might be suggested.
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Eur Rev Med Pharmacol Sci · Jan 2014
Randomized Controlled TrialEffect of a high monounsaturated vs high polyunsaturated fat hypocaloric diets in nonalcoholic fatty liver disease.
Hyperaminotransferasemia is an important problem in obese patients. We decide to examine the changes in hyperaminotransferasemia after weight reduction in obese patients with and without NAFLD secondary to a high monounsaturated fat vs. a high polyunsaturated fat hypocaloric diets. ⋯ We showed that weight reduction secondary to two hypocaloric diets was associated with improvement in hypertransaminasemia and insulin resistance in NAFLD patients.
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Eur Rev Med Pharmacol Sci · Jan 2014
Impact of perioperative lidocaine infusion and bis monitorization on remifentanil dosage in hypotensive anesthesia.
Combination of local and regional anesthetic agents are widely used in emergency and surgical setting and the interaction between the medications used in general anesthesia and these local and/or regional anesthetic becomes a growing concern in current patient management system. The interaction between general anesthetic agents and the local anesthetic agents given epidurally, spinally, intravenously or intramuscularly and the effects of BIS monitorisation on combined propofol-remifentanil anesthesia are examined in several studies. In literature, there is no research investigating the effect of lidocaine infusion on remifentanil and anesthetic dosage used in hypotensive anesthesia. The aim of this study is to examine this effect. ⋯ We found no statistically significant difference between two groups about different parameters. But new investigations with different local anesthetic agents may show sigificant difference and usage of these local anesthetic agents may be advised.
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Eur Rev Med Pharmacol Sci · Jan 2014
The outcomes of surgical treatment modalities to decrease "near miss" maternal morbidity caused by peripartum hemorrhage.
The treatment of patients with peripartum hemorrhage is unfortunately characterized by inadequate treatment that does not adhere to standard therapeutic measures. ⋯ The efficiency of B-Lynch compression brace sutures and the Bakri balloon uterine tamponade system is unpredictable in terms of the need for hysterectomy for peripartum hemorrhage patients diagnosed as either uterine atony or placenta previa. Regardless of the initial diagnosis, these modalities seem to be more effective in alleviating peripartum hemorrhage when accompanied by hypogastric artery ligation.