European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Aug 2016
Clinical significance of up-regulated lncRNA NEAT1 in prognosis of ovarian cancer.
The purpose of the present study was to examine the expression levels of lncRNA NEAT1 in fresh ovarian cancer (OC) tissue and matched adjacent normal tissue specimens, and investigate the clinical significance of NEAT1 in OC. ⋯ These results suggest that NEAT1 has a potential to function as a clinical biomarker for predicting disease invasiveness and prognosis of patients with OC.
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Eur Rev Med Pharmacol Sci · Aug 2016
Dexmedetomidine regulate the malignancy of breast cancer cells by activating α2-adrenoceptor/ERK signaling pathway.
Breast cancer is one of the most aggressive and pervasive cancers identified in females. Dexmedetomidine (Dex) is an efficient anesthetic used in surgery. Our study aimed to explore the role of Dex in the malignancy of breast cancer cells in vitro and in vivo. Further, we investigate the molecular mechanism involved in the function of Dex on breast cancer cells. ⋯ These data suggest that Dex could promote the proliferation, migration and invasion of breast cancer cells through the activation of α2B-adrenoceptor /ERK signaling.