European review for medical and pharmacological sciences
-
Eur Rev Med Pharmacol Sci · Jul 2017
Efficacy of femoral nail anti-rotation of helical blade in unstable intertrochanteric fracture.
We analyzed the comparative efficacy and long-term prognosis with proximal femoral nail anti-rotation (PFNA) and dynamic hip screw (DHS) for the treatment of unstable intertrochanteric fractures, retrospectively. We determined the independent risk factors to guide subsequent surgery and improve the long-term quality of life. ⋯ Compared with DHS, PFNA resulted in better clinical outcomes and long-term prognosis of unstable intertrochanteric fractures.
-
Eur Rev Med Pharmacol Sci · Jul 2017
Retracted PublicationMiR-24 alleviates cardiomyocyte apoptosis after myocardial infarction via targeting BIM.
Ischemia hypoxia induces cardiomyocyte (CM) apoptosis in the process of acute myocardial infarction (AMI). It was showed that pro-apoptosis factor BIM participates in regulating tumor cell apoptosis under ischemia or hypoxia condition, while its role in CM apoptosis after AMI is still unclear. It was revealed that miR-24 expression was significantly reduced in myocardial tissue after AMI. Bioinformatics analysis exhibits that miR-24 is targeted to the 3'-UTR of BIM. This study aims to investigate the role of miR-24 in mediating BIM expression and CM apoptosis. ⋯ MiR-24 was reduced, whereas BIM was enhanced in the CM after AMI. MiR-24 up-regulation plays a critical role in decreasing BIM expression, reducing CM apoptosis, and improving cardiac function after AMI.