European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Feb 2019
Effect of isoflurane on myocardial ischemia-reperfusion injury through the p38 MAPK signaling pathway.
To investigate the effect of isoflurane on myocardial ischemia-reperfusion injury through the p38 mitogen-activated protein kinase (MAPK) signaling pathway. ⋯ Isoflurane can, through inhibiting the p38 MAPK signaling pathway, effectively protect the cardiac function of rats from myocardial ischemia-reperfusion injury, reduce the area of myocardial infarction, alleviate the pathological damage in myocardial cells and reduce the oxidative stress response.