European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Sep 2019
Retracted PublicationKnocking down PFL can improve myocardial ischemia/reperfusion injury in rats by up-regulating heat shock protein-20.
To investigate the effect and mechanism of long non-coding ribonucleic acid (lncRNA) PFL on myocardial ischemia/reperfusion (I/R) injury in rats, and to provide a reference for the prevention and treatment of myocardial infarction (MI) in clinic. ⋯ We found that PFL knockdown can significantly improve the myocardial injury caused by I/R and improve the cardiac function in rats. The mechanism may be related to the activation of HSP-20 by PFL siRNAs. Therefore, PFL is expected to become a new target for the treatment of MI.