European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Apr 2021
Efficacy of intranasal ketamine for acute pain management in adults: a systematic review and meta-analysis.
This study aimed to compare the efficacy of intranasal (IN) ketamine for pain control with placebo and other analgesics in an emergency setting. ⋯ There may be a role of IN ketamine for acute pain management in adults in an emergency setting. There is a tendency for better pain control with IN ketamine as compared to control and the possibility of similar efficacy of IN ketamine as compared to opioids. However, the results are not unequivocal and are limited by the low number of studies in literature and limited pain indications studied. Further RCTs are required to strengthen the evidence.