European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Apr 2016
Randomized Controlled TrialThe administration sequence of propofol and remifentanil does not affect the ED50 and ED95 of rocuronium in rapid sequence induction of anesthesia: a double-blind randomized controlled trial.
The topic of drug administration sequence in rapid sequence induction (RSI) is still an object of interest in terms of rocuronium effectiveness. The aim of this prospective, randomized trial was to evaluate the effect of administration sequence of propofol and remifentanil on ED50 and ED95 of rocuronium in a RSI model. ⋯ The choice of administration sequence of propofol and remifentanil does not have an impact on estimated ED50 and ED95 of rocuronium in providing acceptable intubation conditions in the RSI technique.
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Eur Rev Med Pharmacol Sci · Apr 2016
Interhemispheric functional and structural alterations and their relationships with alertness in unilateral temporal lobe epilepsy.
Many neuroimaging studies have shown that temporal lobe epilepsy (TLE) is associated with functional and structural abnormalities at specific brain areas. Unfortunately, relatively limited information has been presented about the alterations of interhemispheric functional and anatomic connectivity in patients with unilateral TLE. In the present study, we investigated interhemispheric functional connectivity using a voxel-mirrored homotopic connectivity (VMHC) method. We further revealed fractional anisotropy (FA) changes in the areas with abnormal VMHC values in TLE patients by diffusion tensor imaging (DTI). Moreover, their relationships with alertness in patients with drug-naïve unilateral TLE were also investigated. ⋯ Our findings indicate that the bilateral parahippocampal gyrus may be important to the pathophysiology of patients with drug-naïve unilateral TLE. The significant correlation between the FA values and alertness indicates that structural changes are involved in the alterations in the alertness network in unilateral right TLE patients.
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Eur Rev Med Pharmacol Sci · Mar 2016
Value of the neutrophil-to-lymphocyte ratio in predicting post-pericardiotomy syndrome after cardiac surgery.
Post-pericardiotomy syndrome (PPS) occurs in 10-40% of patients after cardiac surgery. PPS is considered an autoimmune phenomenon. The neutrophil-to-lymphocyte ratio (NLR) is a novel inflammatory marker that is associated with various cardiovascular diseases. Studies have reported that the NLR increases in certain autoimmune diseases. This study examined whether the NLR is helpful to predict the occurrence of PPS after elective on-pump coronary artery bypass graft (CABG) surgery. ⋯ The postoperative NLR may be useful to predict the development of PPS in patients undergoing on-pump CABG.
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Eur Rev Med Pharmacol Sci · Mar 2016
A study on the role of apoptotic human umbilical cord mesenchymal stem cells in bleomycin-induced acute lung injury in rat models.
We sought to determine whether normal human umbilical cord mesenchymal stem cells and apoptotic human umbilical cord mesenchymal stem cells play any role in the lung repair following bleomycin-induced lung injury in rat models. ⋯ Human umbilical cord mesenchymal stem cell transplantation may have a bright future in the clinical setting for the treatment of ALI/acute respiratory distress syndrome (ARDS). Apoptotic human umbilical cord mesenchymal stem cells may have more effective than normal human umbilical cord mesenchymal stem cells in the treatment of acute lung injury.
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Eur Rev Med Pharmacol Sci · Jan 2016
Randomized Controlled TrialPregabalin administered as an anxiolytic agent in ultrasound-guided infraclavicular block: a controlled, double-blind, dose-ranging trial.
Adjuvant agents, given with local anesthetics or via venous, oral, or rectal routes for peripheral nerve blocking, have been in use for a long time. Literature studies about pregabalin usage in peripheral nerve blocking are limited in number. In this study, we aimed to reveal the blocking quality of pregabalin administered orally in various doses as an anxiolytic agent and its effective dose range. ⋯ The patients, who are about to undergo surgery, generally develop anxiety about death, not waking up from anesthesia, disability, pain and loss of ability to work. Pregabalin is an anti-epileptic, analgesic and anxiolytic agent. With these characteristics, it can be used to reduce pre-operative anxiety, for prophylaxis against convulsions and post-operative analgesia. One hundred fifty mg of pregabalin provides sufficient and effective analgesia, and this dose positively affects the quality of the block.