European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Jan 2016
The effect of permissive hypotension in combined traumatic brain injury and blunt abdominal trauma: an experimental study in swines.
Optimal hemodynamic resuscitation strategy of the trauma patient with uncontrolled hemorrhage and severe head injury in the pre-hospital setting remains a special challenge. Permissive hypotension prior to definite surgical haemostasis promotes coagulation, decreases blood loss and favors survival. However, hypotension is associated with poor outcome in severe head injury. The purpose of this experimental animal study was to assess the impact of permissive hypotension on survival, hemodynamic profile and brain oxygenation parameters before and/or after definite surgical haemostasis. ⋯ Permissive hypotension by delaying fluid resuscitation up to definite surgical haemostasis improves survival, hemodynamics and allows restoration of cerebral oxygenation in severe head injury.
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Eur Rev Med Pharmacol Sci · Jan 2016
BNP shows myocardial injury earlier than Troponin-I in experimental carbon monoxide poisoning.
In this study, our purpose was to determine whether plasma BNP level can be useful or not in determining the severity of myocardial injury formed by CO poisoning and to compare plasma BNP level with serum cTnI level. ⋯ It was found that BNP levels increased earlier than cTnI levels in acute severe CO poisoning. BNP levels of the cases which were determined to have increased cTnI levels showing myocardial injury increased as well. BNP can show myocardial injury and its severity in acute CO poisoning.
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Eur Rev Med Pharmacol Sci · Dec 2015
ReviewClinical applications of sodium oxybate (GHB): from narcolepsy to alcohol withdrawal syndrome.
Gamma-hydroxybutyrate (GHB) is a short chain fatty acid endogenously produced within the central nervous system (CNS) and acts as a precursor and metabolite of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Although, it is an illegal recreational drug of abuse, its sodium salt (sodium oxybate) has been utilized as a medication for a number of medical conditions. The first aim of this review was to focus on current applications of sodium oxybate for the treatment of narcolepsy, with a particular emphasis on the key symptoms of this disorder: cataplexy and excessive daytime sleepiness (EDS). ⋯ However, there is limited randomized evidence and, thus, GHB cannot be reliably compared to clomethiazole or benzodiazepines. Some randomized data suggest that GHB is better than naltrexone and disulfiram regarding abstinence maintenance and prevention of craving in the medium term i.e. 3-12 months. It is recommended that GHB should be used only under strict medical supervision, since concerns about the abuse/misuse of the drug and the addiction potential have been arisen.
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Eur Rev Med Pharmacol Sci · Dec 2015
Middle-period curative effect of posterior lumbar intervertebral fusion (PLIF) and interspinous dynamic fixation (Wallis) for treatment of L45 degenerative disease and its influence on adjacent segment degeneration.
To study middle period curative effect of posterior lumbar intervertebral fusion (PLIF) and interspinous dynamic fixation (Wallis) in the treatment of L45 degenerative disease and its influence on adjacent segment degeneration. ⋯ Both PLIF and Wallis methods are effective for the treatment of lumbar degenerative disease of L45. Wallis operation has slight advantage in slowing down the speed of intervertebral disc degeneration in the upper adjacent segment of the patient.
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Eur Rev Med Pharmacol Sci · Dec 2015
Randomized Controlled TrialEvaluation of the effects of intrathecal bupivacaine-dexmedetomidine for lumbar spine fusion: a double blinded randomized controlled study.
To evaluate the efficacy of intrathecal dexmedetomidine at improving the quality of the operative field, and prolonging the duration of sensory block, motor block, and postoperative analgesia during spinal surgery ⋯ Intrathecal bupivacaine-dexmedetomidine improved the quality of the operative field, prolonged the duration of the sensory and motor block, prolonged postoperative analgesia, and produced minimal side effects.