European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Jan 2015
ReviewSusac syndrome--clinical insight and strategies of therapy.
Susac syndrome is an uncommon autoimmune microangiopathy characterized mainly by neurological disorders and, to date, 304 clinical cases have been described. The background of this syndrome is an immune-mediated endotheliopathy that affects the microvasculature of the brain, retina, and inner ear resulting in encephalopathy, hearing loss, and branch retinal artery occlusions. ⋯ Magnetic resonance imaging, retinal fluorescein angiography, and audiography findings enable the diagnosis of this syndrome. In this review, we have demonstrated the epidemiology and pathology of Susac syndrome with detailed description of clinical signs, diagnostic procedures and therapeutic possibilities.
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Eur Rev Med Pharmacol Sci · Jan 2015
Clinical TrialPregabalin versus sertraline in generalized anxiety disorder. An open label study.
Generalized Anxiety Disorder (GAD) is a chronic mental illness with a prevalence of 5-7% in the general population. t GAD is characterized by extreme persistent worry, mostly about minor problems, involving pathological fear with high occurrences of vegetative disturbance. GAD leads to functional impairment and a significantly reduced patient's quality of life. According to the guidelines of the World Federation of Societies of Biological Psychiatry (WFSBP), the first-line treatments for GAD are Serotonin selective reuptake inhibitors (SSRIs), Selective serotonin- and norepinephrine reuptake inhibitors (SNRIs) and pregabalin, an atypical anxiolytic. In this study, both efficacy and tolerability of pregabalin were evaluated and compared with efficacy and tolerability of sertraline, an SSRI antidepressant. ⋯ Efficacy and tolerability of pregabalin were high. Compared to sertraline, pregabalin showed more rapid onset of action and equal efficacy. Adverse reactions are short-lasting and the dose depends. Our investigation showed that pregabalin, an atypic anxiolytic is efficient and well tolerable in treatment of GAD.
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Eur Rev Med Pharmacol Sci · Jan 2015
Observational StudyPredictive value of bedside tests for difficult intubations.
The aim of this study is to find the ideal test(s) for the prediction of difficult laryngoscopic intubation. ⋯ The findings suggest that the sternomental distance and neck circumference combination may be a more accurate predictor of difficult intubation.
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Eur Rev Med Pharmacol Sci · Jan 2015
Transfusion of stored red blood cells in critically ill trauma patients: a retrospective study.
The many published studies on the effects of the transfusion of stored red blood cells on clinical outcomes yielded discordant results. Therefore, we chose to study patients with severe trauma. The clinical outcomes considered included in-hospital mortality, the occurrence of sepsis, length of stay in intensive care unit and in hospital, and days of mechanical ventilation. ⋯ Patients with major trauma transfused with old (≥14 days) red cells had a longer length of stay in intensive care unit and in hospital, without any difference in mortality, occurence of sepsis or days of mechanical ventilation.
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Eur Rev Med Pharmacol Sci · Jan 2015
Treatment of different-aged children under bispectral index monitoring with intravenous anesthesia with propofol and remifentanil.
To investigate the changes in bispectral index (BIS) to determine the controllability and safety of intravenous anesthesia with propofol and remifentanil in different-aged children. ⋯ Anesthesia is stable and safe when the same unit doses of propofol and remifentanil are administered to different-aged children. In infants under three months, the BIS values were lower, with prolonged palinesthesia time.