Zhonghua yi xue za zhi
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Zhonghua yi xue za zhi · Jul 2002
[Expression of osteopontin mRNA and its protein in colorectal cancer and liver metastatic tissues].
To investigate the expression of osteopontine (OPN) in colorectal cancer and liver metastatic tissues and the significance of OPN in tumorigenesis and liver metastasis of colorectal cancer. ⋯ The expression of OPN mRNA is the highest in liver metastatic tissues, moderate in primary colorectal cancer tissues, and lowest in adjacent normal tissues of the metastatic liver cancer. OPN protein is located in cytoplasm of colorectal cancer cells. OPN is a potential marker for liver metastasis of colorectal cancer.