Zhonghua yi xue za zhi
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Zhonghua yi xue za zhi · Jan 2008
[The role of mitogen-activated protein kinase cascades in inhibition of proliferation in human prostate carcinoma cells by raloxifene: an in vitro experiment].
To investigate the role of mitogen-activated protein kinase (MAPK) in the apoptosis and cell cycle arrest of human prostate carcinoma cells induced by raloxifene (RAL). ⋯ RAL inhibits the proliferation and induces the apoptosis and G(1) cell cycle arrest via MAPK cascades in human prostate carcinoma cells. Up-regulation of P21(WAF1) mRNA expression by activating ERK1/2 and down-regulation of cyclinD1 by activating p38 induces G(1) cell cycle arrest in the human prostate carcinoma cells. The ERK1/2 or p38 cascade is involved in the induction of apoptosis by RAL. The activation of ERK1/2 increases the expression of Bax. The activation of p38 phosphorylates Bcl-2 then inactivates Bcl-2.
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Zhonghua yi xue za zhi · Jan 2008
[Protective effect of urinary trypsin inhibitor on injury after intestinal ischemia-reperfusion: experiment with rats].
To investigate the mechanism of the injury of intestinal mucosal induced by intestinal ischemia-reperfusion and the protect effects of Urinary Trypsin Inhibitor (UTI). ⋯ Intestinal ischemia-reperfusion may result in intestinal mucosal damage, the mechanism may be involved in the release of abnormal TNF-alpha, NO, reactive oxygen and activated PMN; UTI can protect intestinal mucosal against intestinal ischemia-reperfusion injury, which may be associated with inhibiting the release of NO and TNF-a, ameliorating reactive oxygen damage, decreasing the aggregation and activation of PMN.
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Zhonghua yi xue za zhi · Jan 2008
[Electrophysiological properties of outward voltage-gated potassium channels of neural stem cells from adult rat hippocampus].
To explore the electrophysiological properties of outward voltage-gated potassium channels of neural stem cells (NSCs) from adult rat hippocampus. ⋯ The cultured NSCs of adult rat hippocampus express at least three kinds of outward voltage-gated potassium channels, I(DR), I(A), and BKCa in vitro.