Zhonghua yi xue za zhi
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Zhonghua yi xue za zhi · Feb 2012
Randomized Controlled Trial Multicenter Study Comparative Study[Hemodynamic and efficacies of domestic levosimendan versus dobutamine in patients with acute decompensated heart failure].
To compare the hemodynamic effects of domestic levosimendan versus dobutamine on patients with acute decompensated heart failure (ADHF). ⋯ As compared with dobutamine, domestic levosimendan may bring about better outcomes of hemodynamics and dyspnea.
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Zhonghua yi xue za zhi · Feb 2012
[Effects of vascular endothelial growth factor vector on vascular buds of vertebral cartilaginous endplate in rabbits].
To directly inject recombinant pcDNA3.1-VEGF165 plasmid into degeneration intervertebral disc and explore its effects on vascular buds of vertebral cartilage endplate and intervertebral disc in rabbits. ⋯ The pcDNA3.1-VEGF165 plasmid may promote the vascular buds of vertebral cartilage endplate by increasing their average number and diameter and arresting the intervertebral disc degeneration.
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Zhonghua yi xue za zhi · Feb 2012
[Role of cannabinoid 2 receptor in the development of bone cancer pain].
To explore the effects of cannabinoid 2 receptor (CB2) in the development of bone cancer pain in mice. ⋯ The cannabinoid 2 receptor plays an important role in the formation of bone cancer pain.
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Zhonghua yi xue za zhi · Feb 2012
[Changes of glycogen synthase kinase-3β and its phosphorylation in spinal cord neurons in rats with incisional pain-remifentanil-induced hyperalgesia].
To investigate the change in glycogen synthase kinase-3β (GSK-3β) in spinal cord neurons in rats with incisional pain (IP)-remifentanil-induced hyperalgesia. ⋯ These data indicate that the increased GSK-3β activity in rats spinal cord neurons is involved in remifentanil-induced hyperalgesia.
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Zhonghua yi xue za zhi · Feb 2012
[Clonidine and dexmedetomidine's effect on the altered expressions of growth associated protein-43 mRNA in rat dorsal root ganglion during the development of chronic neuropathic pain].
To explore the effects of α(2) adrenergic receptor (α(2)AR) agonists clonidine and dexmedetomidine on the injury model of peripheral nerve chronic constriction in rats. ⋯ Clonidine and dexmedetomidine both show evident analgesic effects on chronic neuropathic pain in rats probably through a reduction of nerve regeneration. But dexmedetomidine has a better efficacy due to of its high selectivity of α(2)AR.