Zhonghua yi xue za zhi
-
Zhonghua yi xue za zhi · May 2016
[Effectiveness and safety of conversion therapy with the combination of sirolimus with low dose cyclosporine in renal transplantation recipients: a five-year clinical observation].
To assess the effectiveness and safety of the conversion therapy from traditional cyclosporine (CsA) triple immunosuppression therapy to sirolimus (SRL) combined with low dose CsA and prednisone (Pred) in renal transplantation recipients in a five-year follow-up period. ⋯ The combination therapy of SRL and low dose of CsA is overall a safe and effective maintenance immunosuppressive regimen, but it is important to initiate at an appropriate stage. More favourable long-term benefits may be obtained from the conversion therapy in patients with normal or only slightly impaired renal graft function. It may offer an option of individualized immunosuppressive therapy after renal transplantation.
-
To investigate the protective effects of Notch1 on myocardial ischemia reperfusion injury and explore underlying molecular mechanism. ⋯ As an endogenous cardioprotective factor, Notch1 reduces myocardial ischemia reperfusion injury by promoting GSK-3β phosphorylation, inhibiting cardiomyocyte apoptosis and reducing ROS formation.
-
Zhonghua yi xue za zhi · May 2016
[Effect of metanephric mesenchymal stem cells after renal ischemia reperfusion injury in mice].
To study the effect of metanephric mesenchymal stem cells (MMSCs ) after renal ischemia reperfusion injury (IRI). ⋯ MMSCs have a certain repairing effect on renal IRI, accompanied by an increase in miR-26a expression.
-
Zhonghua yi xue za zhi · May 2016
[Analysis of outcomes and learning curve of endoscopic transsphenoidal surgeries for 124 patients with pituitary adenomas].
To investigate the outcomes of the Endoscopic transsphenoidal surgery for patients with pituitary adenomas, analyze the learning curve and provide reference for future surgeries. ⋯ Endoscopic transsphenoidal pituitary adenoma resection has the advantages of wider surgical field, higher GTR rate, less trauma, fewer complications and better life quality of patients.Through standardized learning, the GTR rate of the invasive pituitary adenomas can be improved.
-
Zhonghua yi xue za zhi · May 2016
[Clinical Analysis of Surgical treatment of long bone metastases].
To evaluate the safety and efficacy of microwave ablation combined with curettage in the treatment of long bone metastases. ⋯ Microwave ablation combined with curettage appears to be a safe and effective approach in the surgical treatment of long bone metastases, which can relieve local pain and control the local development of bone metastases.