Biulleten' eksperimental'noĭ biologii i meditsiny
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Biull Eksp Biol Med · Nov 1984
[Experimental prostaglandin E2 therapy of acute kidney failure due to the crush syndrome].
It has been shown for the first time that intraaortal injection of PGE2 to dogs with acute renal failure caused by the crush syndrome makes renal function (glomerular filtration, tubular reabsorption, renal plasmaflow, maximal tubular secretion, minute and diurnal diuresis) return to normal.
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A study was made of the possibility of forming nicotine addiction in laboratory rats and using it as the basis for the design of experimental nicotine toxicomania. Experiments were carried out on 56 rats placed in individual cages with a possibility of free choice between water and 0.005% nicotine solution for 2 to 4 months. ⋯ These quantitative relationships remained unchanged whatever the time of contact with nicotine. Thus, the possibility has been shown of designing experimental nicotine toxicomania with marked elements of physical dependence in rats consuming nicotine on a voluntary basis.