Archives of pediatrics & adolescent medicine
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Arch Pediatr Adolesc Med · Nov 2007
Randomized Controlled TrialA randomized controlled trial of fluoxetine and cognitive behavioral therapy in adolescents with major depression, behavior problems, and substance use disorders.
To evaluate the effect of fluoxetine hydrochloride vs placebo on major depressive disorder, substance use disorder (SUD), and conduct disorder (CD) in adolescents receiving cognitive behavioral therapy (CBT) for SUD. ⋯ Fluoxetine and CBT had greater efficacy than did placebo and CBT on one but not both depression measures and was not associated with greater decline in self-reported substance use or CD symptoms. The CBT may have contributed to higher-than-expected treatment response and mixed efficacy findings, despite its focus on SUD.
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To evaluate whether hypoalbuminemia on admission is a predictor of adverse outcome in critically ill children. ⋯ Admission hypoalbuminemia is a significant marker of morbidity and mortality in critically ill children.