Giornale italiano di cardiologia
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A case of a 46 year old man in whom acute myocardial infarction was the earliest outstanding clinical manifestation of an acute promyelocytic leukemia is reported. Reinfarction occurred a few days after, causing death of the patient. autopsy and histologic findings are reported and pathogenetic hypothesis are discussed. The Authors point out the role of an ipercoagulable state created by leukemia itself.
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[Effect and action mechanism of hypothermia to preserve the ischaemic myocardium (author's transl)].
The ability of hypothermia (34 degrees, 28 degrees) to preserve cardiac metabolism and performance during ischemia, was evaluated in the isolated Langendorff perfused rabbit heart. The hearts, isolated and perfused aerobically for 20', were made ischemic for 90' and their wall temperature maintained either at 37 degrees, 34 degrees and 28 degrees. The hearts were consequently reperfused at 37 degrees for 30'. ⋯ That was coincident with and almost complete recovery of mechanical performance. Hypothermia at 34 degrees during ischemia provoked only a partial protection. These results are discussed in accordance with the hypothesis that hypothermia protects heart muscle against the deleterious effects of ischemia not only by reducing the metabolic requirement but also by maintaining intracellular homeostasis with respect to Ca++.